Scale your growth with Pennsylvania's best accelerators & incubators

Discover the Behind The Scenes of how everyday start-ups grow into unicorns.

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Choosing The Right Accelerator

Start-ups are hard. Choose an accelerator that guides you in the right direction.

Patrick Collison, Founder of Stripe

"I doubt that Stripe would have worked without YC. It's that simple."

Patrick Collison, Founder, Stripe

Chris Lynch, Founder of Atlas Venture

"Accelerators claim they are in it for the long haul — I call bullshit"

Chris Lynch, Founder, Atlas Venture

Raj Aggarwal, Founder of Localytics

"The network we built with Techstars was incredibly valuable during and after the program."

Raj Aggarwal, Founder, Localytics

What truly matters

Figuring what’s in it for you

Accelerator’s connections in the industry

Understand your equity’s true worth

Look for partners not investors

Discover your perfect match

No accelerator or incubator is perfect for every start-up. Your business’s context and constraints matter. Identify your perfect match by answering this short questionnaire.

Pennsylvania's Top Accelerators By Neighborhoods

Comparing Accelerators

NameAerial ScoreStandard DealAddress#Investments#ExitsDetails
Innovation Works6.9$100KTwo Allegheny Center, Suite 100, Pittsburgh, PA 15212, USA51234Learn more
Ben Franklin Technology Partners of Central and Northern Pennsylvania6.3$500K5240 Knowledge Pkwy, Erie, PA 16510, USA23240Learn more
AlphaLab5.0$100K for 2% equityPennsylvania, USA1047Learn more
Comcast NBCUniversal5.0Pennsylvania, USA332Learn more
Robotics Factory5.0113 47th St, Pittsburgh, PA 15201, USA6Learn more
Sustainable Energy Fund4.94250 Independence Dr #100, Schnecksville, PA 18078, USA1Learn more
University of Pennsylvania - Wharton4.8Walnut St, Philadelphia, PA 19104, USA101Learn more
Comcast LIFT labs4.8Pennsylvania, USA405Learn more
Pittsburgh Life Sciences Greenhouse4.72403 Sidney St, Pittsburgh, PA 15203, USA525Learn more
Dreamit Healthtech4.71617 John F Kennedy Blvd floor 20 suite 2020, Philadelphia, PA 19103, USA547Learn more
Comcast NBCUniversal LIFT Labs Accelerator, Powered by Techstars4.6Pennsylvania, USA381Learn more
LSGPA: The Life Sciences Greenhouse of Central PA4.63211 N Front St #201, Harrisburg, PA 17110, USA182Learn more
Life Sciences Greenhouse of Pennsylvania4.63211 N Front St #201, Harrisburg, PA 17110, USA172Learn more
Pennovation Center4.63401 Grays Ferry Ave, Philadelphia, PA 19146, USA101Learn more
AlphaLab Gear4.6$50K113 47th St, Pittsburgh, PA 15201, USA132Learn more
Launch Lane Digital Health4.5up to $400KPhiladelphia, PA, USA141Learn more
AlphaLab Health4.5100 S Jackson Ave, Pittsburgh, PA 15202, USA22Learn more
SteelBridge Labs4.5up to $1M2818 Smallman St, Pittsburgh, PA 15222, USA121Learn more
Steel Bridge Labs4.5up to $1M2818 Smallman St, Pittsburgh, PA 15222, USA121Learn more
Ascender4.56401 Penn Ave 3rd floor, Pittsburgh, PA 15206, USA11Learn more

This page covers the top accelerators and incubators in Pennsylvania.

However if geography isn’t a hard constraint, and you are only looking for the best incubators and accelerators across the US, check here.

Brief Overview Of Different Accelerators

1) Innovation Works

Innovation Works - a prominent start-up growth supporter in Pennsylvania

This pivotal organization is dedicated to enhancing the startup and entrepreneurial ecosystem in Southwestern Pennsylvania, positioning the region as a hub for innovative startups and tech investors nationwide. It plays a critical role in injecting capital, business expertise, and resources into companies that promise significant regional economic impact. Since its inception in 1999, over $117 million has been invested in more than 667 companies, leading to 77 exits and generating over $3.3 billion in follow-on investments. Funding for the AlphaLab and AlphaLab Gear accelerators has notably increased to $100,000 per cohort company upon meeting milestone goals. The institution operates across a diverse range of industries, including biotech, clean energy, consumer electronics, fintech, healthcare tech, robotics, and SaaS. Lisa Greenleaf is acknowledged as a key founder, guiding the vision in fostering sustainable growth. The IW+MC Accelerator, part of this initiative, is a six-month program focused on assisting social enterprise leaders in the Baltimore area. It provides tailored support, a structured curriculum, and access to local as well as global mentors, ensuring participants leave with actionable growth plans and refined business strategies.

Innovation Works's Website
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2) Ben Franklin Technology Partners of Central and Northern Pennsylvania

Ben Franklin Technology Partners of Central and Northern Pennsylvania - supporting founders in their growth journey

Ben Franklin Technology Partners of Central and Northern Pennsylvania is a renowned accelerator with over 30 years of experience investing in tech startups and small manufacturers across its 32-county footprint. The organization focuses on driving economic growth and job creation by providing funding and support to businesses in industries like Fintech, General Tech, and Real Estate Tech. One of its flagship programs is the TechCelerator, a 10-week business boot camp designed for local entrepreneurs, graduate students, professors, and university researchers looking to launch startups and commercialize innovative products or processes. BFTP/CNP offers phased investments, typically not exceeding $500,000 per startup, over a three to four-year timeframe. The accelerator goes beyond funding to provide essential business support services, mentoring through the Transformation Business Services Network, and opportunities for startups to access follow-on funding. The impact of the organization is evident through its annual BIG IDEA Contests and comprehensive approach to fostering tech innovation in Central and Northern Pennsylvania.

Ben Franklin Technology Partners of Central and Northern Pennsylvania's Website
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3) AlphaLab

AlphaLab - Pennsylvania's true entrepreneurial hub

This nationally-ranked software accelerator, based in Pittsburgh, Pennsylvania, was founded in 2008 by Jim Jen to aid early-stage tech companies with essential resources such as funding, networking, and expert guidance. The program spans six months, during which the organization invests $100,000 in exchange for 2% equity in participating startups. It has made 156 investments to date, leading to over $700 million in follow-on funding. Notably, 65% of participant companies have successfully raised additional funding rounds, with 15 exits facilitated and connections established with two unicorns. The accelerator supports a diverse array of industries, including Augmented Reality, Fintech, Gaming, Healthcare Tech, and Mobile Apps. The program is structured in two phases: the initial three months focus on foundational aspects, while the latter half centers on fundraising preparation, investor introductions, and portfolio showcases. Founders benefit from ongoing access to support resources, including up to $800,000 in follow-on investment and continued access to office space. Success stories from alumni underscore the institution's impact, with participants reporting significant revenue growth and valuable partnerships facilitated through the program.

AlphaLab's Website
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4) Comcast NBCUniversal

Comcast NBCUniversal - connecting start-up founders with success

The SportsTech Accelerator is a prestigious six-month program designed to elevate innovative companies in the sports technology sector. This initiative scouts, coaches, and accelerates the growth of startups aiming to revolutionize the sports experience through technological advancements. Participating startups gain invaluable access to key decision-makers and industry leaders from a consortium that includes NBC Sports, Sky Sports, Comcast Spectacor, and Golf, along with partnerships from organizations like NASCAR, WWE, and the Premier League. Typically, cohorts are composed of six to ten startups, each receiving a personalized growth plan tailored to their unique needs. The program encompasses two weeks at the headquarters in Philadelphia, visits to various offices nationwide, and offers remote work weeks to better support entrepreneurs. By leveraging relationships with industry giants, participants can forge long-term commercial partnerships while actively contributing to the evolution of the sports industry ecosystem. From personalized guidance to networking opportunities, this accelerator stands as a critical platform for startups looking to make a significant impact in sports technology.

Comcast NBCUniversal's Website
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5) Robotics Factory

Robotics Factory - supporting founders in their growth journey

This comprehensive initiative focuses on nurturing and accelerating early-stage robotics startups in Southwestern Pennsylvania. Led by Innovation Works and the Pittsburgh Robotics Network, the program benefits from part of the $63 million Build Back Better Regional Challenge grant awarded by the U.S. Economic Development Administration. The Accelerate Program is an intensive six-month engagement, providing startups access to co-working space, manufacturing resources, and a production-grade prototype scale shop. Participants receive personalized coaching tailored to their specific business needs. Noteworthy startups that have emerged from the program include Aquatonomy, which develops underwater intelligence through autonomous robots; Cell X Technologies, innovating stem cell processing with robotics and AI; Grasp Robotics, creating advanced prosthetics with robotic muscles; Leaficient, leveraging computer vision for indoor horticultural lighting; Velo AI, focused on bicycle safety; and Voaige, which develops AI vision software for labor shortages. The initiative encompasses diverse industries, including agriculture tech, artificial intelligence, healthcare tech, logistics and supply chain, and robotics, establishing a robust ecosystem for innovation in the region.

Robotics Factory's Website
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6) Sustainable Energy Fund

Sustainable Energy Fund - a prominent start-up growth supporter in Pennsylvania

A non-profit organization dedicated to accelerating breakthrough energy innovations aimed at reducing CO emissions and addressing climate change, it provides funding through commercial loans, savings, and purchase agreements specifically designed for businesses engaged in sustainable energy projects. The initiative plays a crucial role by increasing capital flow to sustainable energy innovations and aligning public and private funding effectively. This institution specializes in various domains including renewable energy, energy storage, grid optimization, and energy efficiency, thus supporting a broad spectrum of solutions to enhance energy sustainability. Additionally, the fund serves as a collaborative platform for stakeholders, fostering partnerships and knowledge exchange to tackle the financial and regulatory hurdles associated with bringing these technologies to market. With a focus on driving innovation in clean and renewable energy sectors, it is positioned to make a significant impact on both local and global efforts to combat climate change.

Sustainable Energy Fund's Website
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7) University of Pennsylvania - Wharton

University of Pennsylvania - Wharton - connecting start-up founders with success

An esteemed Ivy League research university, it operates several prominent accelerator programs under the Wharton School. Among these, the Cypher Accelerator, facilitated by the Stevens Center for Innovation in Finance, focuses on startups in the blockchain and crypto sectors. This three-month program provides world-class mentorship, educational resources, and access to leading investors, culminating in a demo day where founders can pitch their innovations. Additionally, the Entrepreneurship Acceleration Program, an online certificate course lasting three months, empowers entrepreneurs with a data-driven toolkit to scale their businesses effectively. Another key initiative is the Analytics Accelerator, occurring each fall and spring semester, where students engage with companies to tackle real-world challenges through machine learning and AI techniques. Collectively, these programs span diverse industries including Artificial Intelligence, Blockchain, Edtech, and Fintech, enabling startups to leverage extensive resources and a rich talent pool for their growth. Notably, it was founded by Benjamin Franklin, reinforcing its legacy of innovation and leadership in business education.

University of Pennsylvania - Wharton's Website
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8) Comcast LIFT labs

Comcast LIFT labs - enabling start-ups to fundraise successfully

The Comcast NBCUniversal LIFT Labs Accelerator, a collaboration with Techstars, connects startup founders with key leaders across the organization to foster long-term partnerships. Launched in 2018, the program focuses on startups in entertainment, media, connectivity, and artificial intelligence, specifically targeting companies that can innovate within these sectors. Over 90% of participants have successfully entered into proofs of concepts, pilots, or commercial agreements with Comcast NBCUniversal and Sky. Since its inception, companies associated with the accelerator have collectively raised over $424 million in funding. The program encompasses a rigorous 12-week curriculum offering tailored strategies and direct access to pivotal decision-makers, significantly enhancing the trajectories of participating startups. In 2023, a generative AI theme was introduced to support the development of next-generation technologies. Additionally, the accelerator features 'Founding in Color,' a docuseries highlighting the experiences of Black and Latino founders. Key figures associated with the initiative include founders Daniel Aaron, Diane Yu, Jan Renner, Julian Brodsky, and Ralph J. Roberts, all of whom contribute to the commitment to empowering diverse entrepreneurial talent.

Comcast LIFT labs's Website
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9) Pittsburgh Life Sciences Greenhouse

Pittsburgh Life Sciences Greenhouse - connecting start-up founders with success

The Pittsburgh Life Sciences Greenhouse is an organization based in Pittsburgh, PA. It specializes in providing capital investments and tailored business growth services to life sciences startups. The institution collaborates with early-stage companies and university spinouts in the healthcare sector, focusing on areas such as digital health, medical devices, and therapeutics. The accelerator program offered by PLSG is a 13-week intensive initiative aimed at advancing startups' progress towards commercialization through mentoring and educational support. They work closely with experienced mentors, corporate partners, and ecosystem innovators to assist local life science ventures. The organization's expertise lies in technologies with the potential to revolutionize healthcare. Participants in the program benefit from a curated curriculum delivered by industry experts, guidance on developing investor-attractive commercialization plans, and support in overcoming healthcare startup-specific challenges. Notable perks include the opportunity for engagement with mentors, talent, corporate partners, and investors. PLSG primarily focuses on industries such as Biotech and Healthcare Tech.

Pittsburgh Life Sciences Greenhouse's Website
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10) Dreamit Healthtech

Dreamit Healthtech - a prominent start-up growth supporter in Pennsylvania

Dreamit HealthTech is a leading venture fund dedicated to empowering digital health, medical device, and diagnostics startups. The accelerator program lasts 14 weeks, focusing on companies that are prepared to scale, particularly those with existing pilots or revenue. Over 100 companies have benefitted from this initiative, which aims to transform healthcare by providing access to customers, coaching, and capital. Through structured Investor Sprints, founders engage in one-on-one meetings with 20-30 top-tier U.S. venture capital and healthcare-focused firms, accelerating the fundraising process. Additionally, the program facilitates Customer Sprints, allowing participants to pitch to 15-25 executive-level decision-makers from over 70 partner organizations, including health systems and pharmaceutical companies. The leadership team includes Partner Adam Dakin, who has co-founded five health tech companies that collectively raised over $60 million, and Senior Associate Elliot Levy, who manages deal flow and operations. The accelerator also benefits from the expertise of its founders: David Bookspan, Elliot Menschik, Michael Levinson, and Steve Welch, creating a robust ecosystem for health tech startups to thrive.

Dreamit Healthtech's Website
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11) Comcast NBCUniversal LIFT Labs Accelerator, Powered by Techstars

Comcast NBCUniversal LIFT Labs Accelerator, Powered by Techstars - promoting the start-ups of tomorrow

The accelerator is a premier innovation program that supports startups in the realms of media, entertainment, and connectivity. Established in 2018, it has successfully guided 43 companies, which have collectively raised over $115 million in funding. The program runs for a rigorous 13-week period, providing startups with one-on-one mentoring from Techstars and facilitating direct collaboration with experts across Comcast NBCUniversal's diverse business sectors. Focusing on key domains such as Smart Sustainable Enterprise, Connected Living, Immersive & Inclusive Experiences, and General Connectivity, the program emphasizes diversity and inclusion, with 50% of the companies being led by founders who are people of color and 33% by women or gender-diverse individuals. Over 70% of participating startups have secured proof of concepts or commercial deals with Comcast, NBCUniversal, and Sky, gaining access to an extensive network that includes NBC, Telemundo, film studios, and Xfinity products. Prominent founders involved in the program include Daniel Aaron, Diane Yu, Jan Renner, Julian Brodsky, and Ralph J. Roberts, ensuring a solid foundation for innovation and opportunity.

Comcast NBCUniversal LIFT Labs Accelerator, Powered by Techstars's Website
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12) LSGPA: The Life Sciences Greenhouse of Central PA

LSGPA: The Life Sciences Greenhouse of Central PA - Pennsylvania's true entrepreneurial hub

Life Sciences Greenhouse Investments is a biotechnology initiative and non-profit organization founded in 2001 and based in Harrisburg, Pennsylvania. Its primary mission is to accelerate economic growth and job creation by commercializing discoveries within the life sciences sector. The organization focuses on advancing healthcare technology and providing support for emerging firms based in Pennsylvania. Established in 2002 through legislation related to the Master Tobacco Settlement Act, it has invested $37 million into 72 companies and projects, generating over $736 million in follow-on funding. This investment significantly enhances the life sciences ecosystem within the state. In January 2023, the organization rebranded to Life Sciences Greenhouse Investments, reflecting its role as a source of capital for entrepreneurs and co-investors. Along with the name change, it relocated its headquarters and introduced a new visual identity. The institution specializes in venture capital, focusing on seed and early-stage funding for the biotech, healthcare technology, and SaaS industries, providing early-stage capital and operational expertise to drive innovation and company growth.

LSGPA: The Life Sciences Greenhouse of Central PA's Website
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13) Life Sciences Greenhouse of Pennsylvania

Life Sciences Greenhouse of Pennsylvania - a modern, innovative hub for start-ups in Pennsylvania

The organization is a public-private venture dedicated to commercializing bioscience technologies that are poised to transform healthcare. Its mission centers on supporting early-stage startups and university spinouts in healthcare domains such as digital health, medical devices, and therapeutics by de-risking the commercialization process. They offer a 13-week intensive accelerator program that propels companies toward commercialization, featuring mentoring, educational components, and culminating in a judged pitch event. Participants benefit from a curated curriculum led by industry experts, alongside workshops, networking events, office hours, and leadership forums, all designed to enhance the growth and success of local life science startups. Experienced mentors, corporate partners, and investors play a crucial role in fostering the entrepreneurial environment. The institution remains a vital resource for ventures in the healthcare tech sector, providing essential support and resources needed for success in today's competitive landscape.

Life Sciences Greenhouse of Pennsylvania's Website
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14) Pennovation Center

Pennovation Center - connecting start-up founders with success

The organization is a pioneering business incubator and laboratory situated within Pennovation Works, strategically designed to bridge researchers, innovators, and entrepreneurs for the commercialization of research discoveries. This facility features collaborative creative spaces, including coworking areas, a cafe, and venues for events and programs, fostering a vibrant community for innovation. A core initiative, the Pennovation Accelerator, is a six-week program that supports local startups in refining their business strategies and broadening their networks. Ideal candidates for this program are at the post-MVP/Proof of Concept stage, with revenue under $500K and capital raised under $1M, covering sectors such as AgTech, Health Tech, and Robotics. Each cohort, comprised of up to 12 companies, engages in weekly educational sessions and is paired with experienced mentors. Participants benefit from three months of free coworker membership, AWS credits, and opportunities to pitch to investors on Pitch Day. Key dates include applications opening on April 10th and program duration from June 12th to July 26th. The initiative honors the legacy of its founder, Benjamin Franklin, by promoting ingenuity and entrepreneurship in the Philadelphia region.

Pennovation Center's Website
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15) AlphaLab Gear

AlphaLab Gear - Pennsylvania's true entrepreneurial hub

AlphaLab Gear is an independent subsidiary accelerator founded in 2013, specializing in hardware, Internet of Things (IoT), and robotics startups. The 30-week program offers up to $100,000 in investment, mentorship from industry experts like Kevin Dowling, Aaron Tainter, and others, as well as networking opportunities. Startups benefit from office space, manufacturing equipment access, and educational sessions. The accelerator is led by key figures like Jessi Mazzoni, Dejana Raggi, Afshan Khan, and Jeff Reed, focusing on domains such as consumer electronics and robotics. Notable founders include Josh McElhattan. Additionally, the organization hosts the annual Hardware Cup, a startup pitch contest awarding $50,000 in investment. With a collaborative workspace that includes artists-in-residence, AlphaLab Gear propels early-stage physical product companies towards successful market entry and scalability.

AlphaLab Gear's Website
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16) Launch Lane Digital Health

Launch Lane Digital Health - building Pennsylvania's entrepreneurial future

The Digital Health Accelerator, operated by the University City Science Center, is dedicated to supporting companies poised to transition from research and development to sales. It offers a comprehensive program that includes funding, collaborative workspace, mentorship, and crucial access to healthcare stakeholders and investors within the Greater Philadelphia area. Each selected organization benefits from a standard deal of up to $50,000 via an uncapped SAFE note, focused on achieving commercialization milestones. In 2021, the fifth cohort comprised eight startups from the U.S. and Canada, collectively receiving $200,000 in initial funding, with an additional $200,000 available as they met specific milestones. Participants engaged in weekly programming tailored to their unique growth needs and received a one-year membership at the ic@3401 incubator. Over its course, the program has supported 35 companies, which collectively raised over $100 million in follow-on funding and generated $50 million in revenue. Notable startups include Clinicor, Gray Oncology Solutions, and Vital Start Health, highlighting the emphasis on equity, mentorship, and community connections that drive innovation in the healthcare sector.

Launch Lane Digital Health's Website
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17) AlphaLab Health

AlphaLab Health - supporting founders in their growth journey

AlphaLab Health was a healthcare and life sciences accelerator that supported early-stage tech startups in bringing innovations to market by navigating scientific, clinical, and commercial development risks. The partnership between Innovation Works and Allegheny Health Network leveraged healthcare domain expertise and clinical access from partners like Highmark Health. The program focused on accelerating scientific, clinical, and market validation for healthcare and life science tech companies, specializing in biotech and healthcare tech industries. It offered resources like clinical access, tailored support, and flexible programming, aiming to empower startups in shortening the road to commercialization. Although specific metrics like start-ups associated or funded start-ups are not provided, the accelerator's commitment to providing key resources and guidance to entrepreneurs seeking to make an impact in the health and life sciences space is remarkable. Key people involved include those from Innovation Works and Allegheny Health Network.

AlphaLab Health's Website
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18) SteelBridge Labs

SteelBridge Labs - building Pennsylvania's entrepreneurial future

An early-stage FinTech incubator located in Pittsburgh, Pennsylvania, with additional offices in Miami, it was founded by experienced management consultants to foster innovation in the financial technology sector. The accelerator specializes in investing in pre- or early-revenue FinTech companies, offering seed capital ranging from $25,000 to $1,000,000, with the potential for co-investment from a network of trusted investors, including High Net Worth Individuals, Family Offices, Corporate Strategics, and Venture Capitalists. The organization provides a structured curriculum and infrastructure, facilitating collaboration among entrepreneurs, coders, investors, and technologists. This supportive environment encourages the development of innovative solutions across various domains, including financial services, payment solutions, blockchain, and data analytics. The leadership team comprises notable founders who are committed to guiding portfolio companies and actively participating in their growth. By being part of this ecosystem, startups receive valuable access to resources and expertise that address real-world challenges in the financial industry.

SteelBridge Labs's Website
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19) Steel Bridge Labs

Steel Bridge Labs - a prominent start-up growth supporter in Pennsylvania

An early-stage accelerator based in Pittsburgh and Miami, this institution is dedicated to supporting FinTech startups. Founded by industry veterans from SteelBridge Consulting, it aims to create a collaborative ecosystem that equips entrepreneurs with the necessary tools, capital, and guidance to address challenges in the financial services sector through innovative software solutions. The program focuses on pre- and early-revenue companies, providing seed funding ranging from $25,000 to $1,000,000, along with potential co-investment opportunities from a network of high net worth individuals, family offices, corporate strategics, and venture capitalists. Specializing in various domains including FinTech, SaaS, and alternative investments, the accelerator offers a structured curriculum and infrastructure designed to help startups evolve their ideas into viable businesses. It fosters a thriving environment, encouraging collaboration among entrepreneurs, coders, investors, and technologists. Key individuals leading the organization include founders James Haluszczak, Luis Burgos, Tim Haluszczak, and Todd Haring. With a comprehensive support strategy and access to a rich investor network, the institution significantly enhances the likelihood of success for its portfolio companies in the competitive financial technology landscape.

Steel Bridge Labs's Website
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20) Ascender

Ascender - accelerating exceptional start-ups in Pennsylvania

This dynamic startup accelerator empowers entrepreneurs by offering a comprehensive suite of resources, including educational programming, mentorship, expert coaching, incubation, and coworking space. The institution fosters business growth across various sectors, particularly focusing on industries such as Artificial Intelligence, Fintech, General Tech, and Software as a Service (SaaS). Their mission is to facilitate scientific development and research projects, exemplified by a GitHub repository template designed to optimize project organization and streamline the development process using Python. Key features of this template include containerization through Docker, virtual environment management with Poetry, automatic code linting and formatting, static type checking with Mypy, and simplified testing via pytest. By providing essential organizational structures and GitHub integration, the organization effectively enhances development efficiency and collaboration for startups. With these resources, it plays a critical role in incubating innovative startups and driving their success in competitive markets.

Ascender's Website
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21) Runway Healthcare

Runway Healthcare - enabling start-ups to fundraise successfully

Runway Healthcare is a MedTech accelerator dedicated to investing in early-stage technologies that significantly transform patients' lives. This Medical Device Venture Studio actively collaborates with entrepreneurial doctors and professionals to bring innovative ideas to fruition. Their investment philosophy, summarized as "Early In, Early Out," emphasizes speed and efficiency, allowing them to manage and invest in early and development-stage MedTech companies swiftly. The organization specializes in medical devices, particularly in orthopedic fields, supporting concepts like vertebral fixation with companies such as Waypoint Orthopedics and Toetal Solutions, which enhances confidence in PIP Fusion for foot and ankle deformities. Pace Surgical is also a collaborator, focusing on foot and ankle fixation enhancements. Beyond capital, they offer extensive experience and expertise to ensure effective product development and technology transfer to multinational firms. With a commitment to operational excellence, this institution is at the forefront of the MedTech landscape, driving innovations that meet pressing healthcare needs.

Runway Healthcare's Website
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22) Penn State Research Foundation

Penn State Research Foundation - a modern, innovative hub for start-ups in Pennsylvania

The organization plays a crucial role in driving economic development, job creation, and enhancing student career success through its innovative initiatives. One prominent program is the Climate Solutions Accelerator, which aims to tackle climate change by fostering collaboration among researchers, industry, government, and community stakeholders. This initiative empowers interdisciplinary research teams by providing essential resources, mentorship, and funding to develop actionable climate solutions. The 2024 program is structured in two levels: workshops that establish and advance teams, and team projects that implement proven solutions at scale within a two-year funding period. While specializing in various fields including renewable energy and sustainable agriculture, the accelerator's place-based engagement addresses the unique challenges of different communities. Founding figures like Evan Pugh have been instrumental in establishing the institution as a leader in promoting agricultural tech, edtech, environmental tech, and renewable energy. Notable startups that have benefited from this initiative exemplify its commitment to fostering impactful research and real-world implementation of climate solutions, ultimately contributing to a sustainable future for Pennsylvania and beyond.

Penn State Research Foundation's Website
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23) Innovation Park at Penn State

Innovation Park at Penn State - supporting Pennsylvania's best founders

This dynamic ecosystem integrates business, education, and research, serving as a fertile ground for startups to flourish. At its core is the TechCelerator Incubator Program, which equips new businesses with essential support and tools to succeed. This initiative boasts an impressive statistic, as 4 out of 5 startups that participate in incubator programs find success within five years. The TechCelerator provides strategic planning, market research, accounting assistance, and access to mentorship, alongside flexible office and lab spaces. The organization specializes in scientific, engineering, technology, and business resources, leveraging the vast expertise of Pennsylvania State University to facilitate knowledge transfer to the marketplace. Spanning 118 acres, it offers comprehensive facilities, including high-speed internet services, a presentation center for showcasing innovations, conference rooms for collaboration, and essential administrative support services. Founded by Evan Pugh, this vibrant community is particularly notable for its focus on industries like Edtech, making it an ideal launching pad for innovative ventures.

Innovation Park at Penn State's Website
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24) Penn State - Farrell Center for Corporate Innovation & Entrepreneurship

Penn State - Farrell Center for Corporate Innovation & Entrepreneurship - Pennsylvania's true entrepreneurial hub

Established in 1992 through an endowment from Michael J. Farrell, the institution is integral to Penn States Smeal College of Business. Its mission focuses on promoting entrepreneurship and innovation as essential management disciplines applicable to enterprises of all sizes. The organization undertakes three primary roles: creating and managing educational programs, conducting research in entrepreneurship and innovation, and fostering outreach and industry partnerships. Notable initiatives include the Propel Business New Venture & Innovation Program, designed to assist graduate students and alumni in new venture creation, and a 12-credit Corporate Innovation and Entrepreneurship Certificate program that equips participants with both theoretical knowledge and practical skills. The center benefits not only students and faculty by providing collaborative opportunities with industry partners but also companies seeking access to fresh talent and expertise. Its scope includes sectors such as Edtech and Healthcare Tech. With a commitment to mentoring and supporting student innovation, it catalyzes successful new ventures within the business ecosystem at Penn State. Notable figures associated with it include founder Evan Pugh, reflecting its strong academic and innovative foundation.

Penn State - Farrell Center for Corporate Innovation & Entrepreneurship's Website
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25) LifeX (United States)

LifeX (United States) - supporting Pennsylvania's best founders

LifeX Labs, founded by Dietrich Stephan, is a biotechnology company in the United States. The organization operates the LifeX Accelerator program, catering to early-stage ventures in the biotech and healthcare tech industries. The accelerator offers a free, 3-month immersive program aimed at ventures focusing on digital health, medical devices, or therapeutics. The Spring 2024 Accelerator program runs from March 19th to June 6th and includes virtual group sessions on Tuesdays and Thursdays from 3-5 PM ET. Through specialized support, the program assists ventures in pharma, medical devices, diagnostics, and digital health sectors. Numerous start-ups have benefited from the program, securing follow-on funding through SBIRs, PHDA, and private investments. Participants receive assistance in developing investable commercialization plans, access to a diverse network of experts, and hands-on support from dedicated mentors and interns. Ventures joining the program are expected to have a proof of concept, validated scientific feasibility, and a commitment to securing necessary IP rights. LifeX Labs has garnered praise from past participants like Shawn K. Kelly and Sam Rothstein for its wealth of information and networking opportunities, making it a valuable resource for entrepreneurs in the life sciences field.

LifeX (United States)'s Website
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26) University of Pittsburgh - Big Idea Center/Blast Furnace Accelerator​

University of Pittsburgh - Big Idea Center/Blast Furnace Accelerator​ - a prominent start-up growth supporter in Pennsylvania

The University of Pittsburgh, a state research university, offers undergraduate, graduate, and other educational services. It hosts the Blast Furnace, a student accelerator program within the Office of Innovation and Entrepreneurship's Big Idea Center. This program runs for eight weeks in the summer, focusing on customer discovery and product-market fit to help Pitt students succeed as entrepreneurs. The Blast Furnace supports multiple student-led startups annually, with a goal to enhance their entrepreneurial success. It welcomes students from diverse disciplines, promoting innovation across various fields. Participants benefit from a deep mentor network, inspirational co-working space, a rich curriculum, and hands-on learning. The program also assists students in gauging the viability of their ideas post-graduation. Founded by Hugh Henry Brackenridge, the Blast Furnace at the University of Pittsburgh specializes in industries like Edtech, providing a nurturing environment for student entrepreneurs to thrive with guidance, practical skills, and a supportive community.

University of Pittsburgh - Big Idea Center/Blast Furnace Accelerator​'s Website
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27) University of Pittsburgh Innovation Institute

University of Pittsburgh Innovation Institute - supporting founders in their growth journey

The University of Pittsburgh Innovation Institute is a key entity dedicated to fostering innovation and entrepreneurship in the university community. Its mission is to support Pitt innovators by providing education, mentorship, and funding to translate initial ideas into impactful solutions, effectively bridging the gap between research and real-world application. As of fiscal year 2023, the organization has been associated with 267 startups, reported 359 invention disclosures, secured 113 U.S. patents, and granted 150 licenses and options. Key programs such as the Blast Furnace student accelerator offer mentor networks, co-working spaces, and a curriculum designed to prepare startups for success. The Pitt Innovation Challenge (PInCh) accelerates bold health-related ideas, while the Pitt Ventures Startup Academy provides tailored guidance for faculty and staff to commercialize intellectual property within a 12 to 18-month timeframe. Specializing in various domains including healthcare, technology, and engineering, it encourages interdisciplinary collaboration. Additionally, the institution facilitates industry engagement, networking, and funding opportunities, making it a dynamic hub that empowers innovators and drives meaningful solutions. Founded by Hugh Henry Brackenridge, it carries a rich legacy in promoting entrepreneurship.

University of Pittsburgh Innovation Institute's Website
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28) Ascender (Pittsburgh)

Ascender (Pittsburgh) - supporting Pennsylvania's best founders

This dynamic startup incubator and educational hub, located in Pittsburgh, is committed to empowering entrepreneurs to launch, build, and grow their businesses. The accelerator runs a comprehensive year-long program specifically designed to equip participants with essential tools for sustainable business development. It supports numerous startups annually across various industries, including software, hardware, retail, healthcare, education, ecommerce, fintech, and social media. Each participant can receive up to $5,000 in equity-free funding, along with one-on-one business coaching from an Entrepreneur-in-Residence, and unlimited access to educational programming tailored to their individual needs. They benefit from a collaborative coworking space available 24/7, technical support for branding and marketing, and connections to an extensive mentor community. Furthermore, the program fosters networking opportunities with a strong alumni network of successful graduates. Entrepreneurs are connected with valuable resources and exposure through digital platforms, ensuring they are well-prepared to navigate the challenges of the entrepreneurial landscape.

Ascender (Pittsburgh)'s Website
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29) Temple University - Innovation and Entrepreneurship Institute

Temple University - Innovation and Entrepreneurship Institute - building Pennsylvania's entrepreneurial future

The Innovation and Entrepreneurship Institute at Temple University's Fox School of Business serves as a significant catalyst for fostering an entrepreneurial spirit across the universitys 17 schools and colleges. The organization promotes an innovative mindset, equipping students with the skills, resources, and confidence essential for disrupting business norms and transforming ambitious ideas into successful ventures. Key programs include the Be Your Own Boss Bowl (BYOBB), where participants pitch their business ideas. In 2023, Neha Raman secured 2nd place and won a $10,000 prize. The 1810 Accelerator provides a collaborative space for early-stage ventures, facilitating knowledge sharing and networking within the entrepreneurial community. The institute also partners with Ben Franklin to invest in promising businesses that arise from Temple-based technologies. Its inclusive approach allows students from diverse backgrounds to engage in entrepreneurship. Additional benefits include customized mentorship, access to respected business strategists in the Philadelphia area, and networking opportunities, thereby creating a rich ecosystem for aspiring entrepreneurs, particularly in industries like Edtech and Healthcare Tech.

Temple University - Innovation and Entrepreneurship Institute's Website
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30) Clarion University - Entrepreneurial Leadership

Clarion University - Entrepreneurial Leadership - supporting Pennsylvania's best founders

PennWest Clarion is a university in Pennsylvania offering a variety of higher education programs and courses. The Entrepreneurial Leadership Center aims to cultivate innovation and entrepreneurial thinking within the university community by providing formal and informal training, a resource knowledge base, and interactive learning opportunities. The center focuses on fostering entrepreneurial thinking across various disciplines, catering to students, staff, and faculty from diverse backgrounds. Students benefit from experiential learning, networking opportunities with successful alumni, assistance in business plan development, and access to a student incubator. The center's commitment to training, resources, and interactive learning makes it a valuable asset for aspiring entrepreneurs at Clarion University. Industries served by the Entrepreneurial Leadership Center include Sector Agnostic.

Clarion University - Entrepreneurial Leadership's Website
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31) PGH Lab

PGH Lab - connecting start-up founders with success

This city-led startup accelerator based in Pittsburgh is dedicated to fostering innovation and development in urban services. The program spans three to four months and specifically connects local startups with city authorities, enabling them to test their products and services in real-world settings. The initiative aims to propel startups from early to growth stages by addressing several priority areas: process improvement and optimization, sustainability and environment, equity and inclusion, and health and safety. Past cohort members have included innovative companies such as AiMiL, which partnered with the Department of Innovation & Performance, Qarar with the Office of Management and Budget, and Velo with the Department of Mobility & Infrastructure. Additional benefits for participating startups include opportunities for networking, valuable feedback, and the chance to pilot solutions that enhance city services. The program actively seeks to innovate local government operations by incorporating new technologies that promote efficiency, transparency, sustainability, and inclusiveness. It supports industries such as Environmental Tech, Healthcare Tech, and Renewable Energy, positioning itself as a crucial driver of positive change within the City of Pittsburgh.

PGH Lab's Website
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32) Shippensburg University - Entrepreneurial Leadership Center

Shippensburg University - Entrepreneurial Leadership Center - Pennsylvania's true entrepreneurial hub

The Charles H. Diller Jr. Center for Entrepreneurial Leadership and Innovation is dedicated to fostering entrepreneurial skills and mindsets among students. Located in Shippensburg, Pennsylvania, this center has a keen mission to develop both the skill set and entrepreneurial mindset necessary to recognize and capitalize on business opportunities. Entrepreneurial leadership entails organizing groups to achieve common goals through proactive behavior, optimizing risk, and effectively managing change. The institution draws inspiration from notable figures like Steve Jobs and Elon Musk, emphasizing that such leadership is not limited to famous individuals but includes innovative students as well. It offers a comprehensive entrepreneurial ecosystem featuring the Milton K. Morgan III Makerspace for hands-on learning, collaboration with the Small Business Development Center, and access to the Brad E. Hollinger Stock Trading Room. Additionally, mentorship and support are provided for students with entrepreneurial aspirations, preparing them for the challenges of the 21st-century business landscape. Through its initiatives, the center plays a crucial role in equipping students with the skills required to succeed in their entrepreneurial endeavors.

Shippensburg University - Entrepreneurial Leadership Center's Website
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33) Bridgeworks Enterprise Center

Bridgeworks Enterprise Center - connecting start-up founders with success

Founded in 1989, the organization known as Bridgeworks Enterprise Center is a distinguished business incubator located in the renovated former Mack Trucks Plant 4A. It stands out as the sole business incubator in the Lehigh Valley exclusively devoted to nurturing manufacturing startups. The organization's core mission revolves around furnishing manufacturing entrepreneurs with the essential resources crucial for their progression from humble beginnings to self-sustaining profitability. While the precise number remains unspecified, it has actively supported numerous manufacturing startups, typically guiding them for a duration of four to seven years before they transition to the City of Allentown or the wider Lehigh Valley region. Specializing in manufacturing ventures, the center offers a spectrum of benefits including shared conference rooms, mentoring services, training sessions, private office suites, a common area indoor loading dock, a shared machine shop, as well as fork trucks and pallet jacks for logistics support. Graduation from the program is based on criteria such as space requirements, self-sustainability, or successful exit events like mergers and acquisitions. Notable for its affiliation with the International Business Innovation Association, Bridgeworks Enterprise Center remains a beacon of support for startups in the manufacturing domain.

Bridgeworks Enterprise Center's Website
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34) Coal Hill Ventures

Coal Hill Ventures - accelerating exceptional start-ups in Pennsylvania

Coal Hill Ventures is a pioneering accelerator and venture capital firm based in Pittsburgh, Pennsylvania, specializing in the investment of ambitious deep tech companies. Founded by Managing Director Christopher Moehle, the firm emerged from Carnegie Mellon's renowned robotics lab, positioning itself at the forefront of the robotics revolution. The organization aims to catalyze industrial transformations by supporting startups that harness cutting-edge technologies in robotics and artificial intelligence. Emphasizing collaboration between humans and machines, this philosophy is integral to its investment strategy. Recognizing Pittsburgh's dense talent pool in advanced robotics, it is committed to leveraging this resource for transformative impact. The firm remains dedicated to fostering innovation in key domains, including Artificial Intelligence, Robotics, and SaaS (Software as a Service). The name 'Coal Hill' pays homage to Mount Washington, a historic landmark integral to the citys legacy and the global steel industry.

Coal Hill Ventures's Website
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35) Startup Bucks

Startup Bucks - accelerating exceptional start-ups in Pennsylvania

This nonprofit accelerator, established in 2019 and located in Bucks County, Pennsylvania, is dedicated to supporting early-stage tech startups. Its primary aim is to drive economic and cultural growth within the region, investing up to $25,000 as a convertible note in at least five early-stage companies biannually. The organization provides essential funding and resources to eligible startups, which include those with no more than five employees and that are incorporated, with an owner who lives or plans to live in Bucks County or intends to operate or hire in the area. Participants in the program benefit from mentorship, pitch coaching, and access to connections with investors. They engage in weekly 1 Million Cups forums and receive additional perks such as a tech stack audit from Coherent Ways and workspace access at Stacks Co. in Doylestown, which was founded by Jon Mercer, a key figure within the institution. The accelerator focuses on innovative, scalable businesses across various industries including Blockchain, Fintech, General Tech, Personal Finance, and SaaS, fostering entrepreneurship and creating opportunities for growth in the local community.

Startup Bucks's Website
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36) Nextfab

Nextfab - supporting Pennsylvania's best founders

NextFab is a collaborative makerspace located in Philadelphia, offering access to digital and traditional fabrication tools, classes, events, and consulting services. The Artisan Accelerator is a structured 9-month program tailored for creative entrepreneurs focused on producing physical products. This program includes 2.5 months of business education covering essential topics such as business models, marketing strategies, and financial management, followed by over 6 months of self-paced product and production coaching. The accelerator primarily supports micro-enterprises with 5 or fewer employees, prioritizing businesses owned by people of color, women, immigrants, and individuals with disabilities. Accepted participants benefit from a dedicated micro-studio or bench rental space, alongside an annual membership which includes up to 24 hours of shop education. The program format is a hybrid of virtual and in-person sessions, facilitating contract work, prototyping, and scaling production. Notable founder Evan D. Malone leads the initiative to empower creative entrepreneurs in the eCommerce and Edtech industries. Additional support is provided through a Facilitation Fund for childcare, transportation, and technology access. Applications opened on May 20th, 2024, and the program aims to foster a vibrant community for artisans and makers.

Nextfab's Website
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37) NextFab

NextFab - a modern, innovative hub for start-ups in Pennsylvania

This collaborative makerspace located in Philadelphia offers a comprehensive range of digital and traditional fabrication tools, classes, and events for individuals of all skill levels. The Artisan Accelerator is a pivotal 9-month program tailored for current and aspiring creative entrepreneurs focused on developing physical products. In 2024, only one cohort will be selected, providing a unique opportunity for 10 applicants. Participants will undergo 2.5 months of rigorous business education, covering essential topics such as business models, marketing strategies, and financial management. Over the subsequent 6 months, they will benefit from self-paced product and production coaching, access to educational resources, and business growth consulting. Selected candidates will receive micro-studio space and comprehensive business services, including shipping and receiving, at the North Philly location. The program is specifically designed for micro-enterprises with 5 or fewer employees, while prioritizing applicants from underrepresented communities. Additionally, a facilitation fund is available to assist with practical support services. Founded by Evan D. Malone, the organization serves a variety of industries, including Agriculture Tech, Clean Energy, Edtech, Healthcare Tech, and Robotics.

NextFab's Website
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38) Dreamit Securetech

Dreamit Securetech - a prominent start-up growth supporter in Pennsylvania

Dreamit Securetech is a venture fund that specializes in startups focused on cybersecurity, anti-fraud, risk & compliance, and physical security. The accelerator specifically targets companies that have deployed a product and demonstrated early traction, including revenue or pilot programs. They engage founders through innovative Customer Sprints and Investor Sprints, providing essential opportunities for networking with leading corporations, technology companies, and venture capital firms. These structured interactions help startups accelerate their customer relationships and fundraising efforts. The program lasts for 14 weeks, offering a tailored environment for those poised for growth. Led by Partner Mel Shakir and Director Drew Hunt, the organization benefits from extensive experience in refining strategies and scaling sales operations for cybersecurity firms. Founded by David Bookspan, Elliot Menschik, Michael Levinson, and Steve Welch, it attracts promising startups in the Securetech domain, ensuring they are well-equipped to scale in todays landscape.

Dreamit Securetech's Website
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39) numo

numo - a modern, innovative hub for start-ups in Pennsylvania

The organization is a technology incubator that primarily supports fintech startups, specializing in industries such as delivery services, logistics and supply chain, and renewable energy. Founded by David Passavant, it is dedicated to fostering innovation and developing advanced solutions in urban mobility and technology. The institution collaborates with a diverse network of partners including cities, research institutions, and corporations to implement impactful pilots aimed at enhancing urban mobility. Notable initiatives include the Move PGH pilot addressing mobility insecurity in Pittsburgh and the Detroit Bike Challenge focused on promoting e-bikes. Additionally, the company leads multiple working groups and coalitions that delve into topics like micromobility and data privacy. By providing valuable resources such as practical guides on measuring accessibility and community-first mobility playbooks, they equip startups with the tools necessary for success. The accelerator emphasizes a collaborative approach, leveraging its extensive network and expertise to drive the mobility sector forward.

numo's Website
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40) Vibrant Pittsburgh Connection Accelerator

Vibrant Pittsburgh Connection Accelerator - supporting founders in their growth journey

An initiative dedicated to fostering diverse talent and promoting equity within the Pittsburgh region's workforce, it aims to increase diversity by attracting, retaining, and promoting individuals from various backgrounds. The program offers mentorship opportunities for college students, connecting them with seasoned business professionals who guide their career exploration and development. Additionally, the organization supports diverse communities through mini grants that fund projects, events, and collaborations focused on enhancing inclusivity. While specific metrics regarding the number of startups or investors involved are not publicly available, it is recognized for its impact in fostering connections, mentorship, and community collaboration. The program addresses a range of industries, including biotech, edtech, fintech, general tech, and healthcare tech. By enhancing networking opportunities and providing access to valuable resources, this initiative plays a pivotal role in cultivating an equitable and inclusive business environment in the region, thereby setting a foundation for a forward-looking workforce.

Vibrant Pittsburgh Connection Accelerator's Website
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41) TiE Pittsburgh

TiE Pittsburgh - enabling start-ups to fundraise successfully

Founded in 2000, this renowned accelerator and incubator is located in Pittsburgh, Pennsylvania. As a non-profit organization, it is dedicated to fostering entrepreneurship by providing crucial mentorship, resources, and networking opportunities. With a total of 10 investments in various sectors, they boast an active portfolio of 8 companies and have achieved 2 successful exits. The focus spans diverse industries, including Biotech, Consumer Electronics, Edtech, Healthcare Tech, and SaaS (Software as a Service). Comprising 2 skilled professionals, the institution supports startups across various domains, encompassing Decision/Risk Analysis, Electronics, Education and Training Services, Drug Discovery, Business/Productivity Software, and more. By offering early-stage support, mentorship, and valuable investor connections, it plays a pivotal role in nurturing the entrepreneurial ecosystem, making it an essential platform for startups seeking growth and success.

TiE Pittsburgh's Website
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42) Tribe 12

Tribe 12 - Pennsylvania's true entrepreneurial hub

This non-profit organization operates a fellowship program designed for entrepreneurial individuals in their 20s and 30s within Philadelphia's Jewish community. The fellowship empowers participants by providing tangible skills and a supportive network. Each fellow works on a capstone project of their own designbe it a new or existing business, non-profit, or community initiativeemphasizing a 'double bottom line' approach where social impact is a key measure of success. The curriculum employs Stanford d.schools Design Thinking Methodology and includes experiential workshops covering essential skills such as prototyping, public speaking, and financial management, while integrating Jewish principles of self-discovery and philanthropy. A significant benefit of the program is its robust network, where each fellow is paired with two mentorsone successful professional and one alumnussupporting them throughout their journey. Participants gain a toolkit of skills, an elevator pitch, and a business plan, which significantly impact local and global communities. The fellowship fosters collaboration among peers and connects them with over 150 alumni and subject matter experts across diverse industries, ensuring that participants can build meaningful, impactful ventures.

Tribe 12's Website
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43) VentureLab (Grove City College)

VentureLab (Grove City College) - supporting Pennsylvania's best founders

The entrepreneurship accelerator program located at Grove City College in Pennsylvania empowers students across all majors to innovate and launch startups, fostering an environment conducive to entrepreneurship and creativity. This initiative supports early-stage ventures by providing essential resources, mentorship from experienced industry leaders, and networking opportunities that connect participants with fellow entrepreneurs and potential investors. Known for hosting workshops, seminars, and training sessions, it enhances entrepreneurial skills in various domains, including technology, social impact, and consumer products. Participants benefit from access to co-working spaces and other vital tools necessary for business development, allowing them to explore their passions and contribute meaningfully to their fields. This comprehensive support system positions the institution as a key player in nurturing the next generation of entrepreneurs and innovators.

VentureLab (Grove City College)'s Website
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44) Wilkes-Barre Connect

Wilkes-Barre Connect - building Pennsylvania's entrepreneurial future

An accelerator focused on helping growth-phase technology and tech-enabled businesses scale successfully, it is operated by the Greater Wilkes-Barre Chamber of Business & Industry. The program spans an intensive duration of 1-3 years and is strategically located in a 5-story building within a Keystone Innovation Zone (KIZ) in Wilkes Barre, PA, offering stunning views of the Susquehanna River. Access to the accelerator is by application only. The program supports startups across various domains including Artificial Intelligence, Cybersecurity, Logistics and Supply Chain, Mobile Apps, Robotics, and SaaS. Tenants receive exclusive services such as Public Relations, Mobile App/Website Development, and IT Consulting, along with invitations to intimate live entertainment experiences on the Special Guest DEMO Stage and tenant-only discounts at local businesses. Founded by serial entrepreneur Kris Jones, known for his investments in over 25 companies, it is also home to the Special Guest App, a talent booking management platform co-founded by actor/comedian Damon Wayans, Jr. and Kris Jones, further enhancing its reputation and influence in the tech community.

Wilkes-Barre Connect's Website
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45) PennHealthX

PennHealthX - supporting founders in their growth journey

The SDoH Accelerator is a program dedicated to supporting early-stage for-profit and not-for-profit startups that aim to improve social determinants of health (SDoHs). This initiative, driven by students from the Perelman School of Medicine (PSOM), provides pro-bono project assistance, covering the costs associated with PSOM consultants to alleviate financial burdens on participating startups. Startups interested in joining the accelerator can apply through a rolling application process, which requires an overview of their organization and a high-level work plan detailing how PSOM student-consultants can assist them. The program specifically targets SDoH areas, including socioeconomic status, education, environment, and healthcare access. By facilitating collaboration between startups and medical students, the accelerator promotes the development of innovative solutions that bridge the gap between healthcare and the social factors influencing health outcomes. This initiative not only enhances the practical experience of the students but also fosters innovation at the intersection of medicine, business, and technology, thereby encouraging impactful ventures within the Edtech and Healthcare Tech industries.

PennHealthX's Website
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46) Smart Health Innovation Lab

Smart Health Innovation Lab - building Pennsylvania's entrepreneurial future

Located in Lancaster, Pennsylvania, this state-of-the-art innovation center was founded in 2017 through a partnership of several key healthcare leaders including Aspire Ventures, Capital Blue Cross, Clio Health, and Penn Medicine Lancaster General Health. Its mission is to advance healthcare innovations that significantly impact cost, experience, and health outcomes for communities. By fostering collaboration among payors, providers, and technology companies, the organization aims to pave a more efficient path toward market adoption and insurance reimbursement for new healthcare technologies. Specializing in transformative domains such as precision medicine, digital health, and innovative devices, it offers startups a supportive environment with mentorship from industry experts and access to enterprise-level opportunities. Serving as an essential accelerator in the healthcare tech and biotech industries, this lab is dedicated to driving innovation and improving the overall patient and provider experience.

Smart Health Innovation Lab's Website
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47) Bentley Systems Acceleration Initiatives

Bentley Systems Acceleration Initiatives - a prominent start-up growth supporter in Pennsylvania

The Bentley Systems Acceleration Initiatives is a strategic investment fund and incubator established by Bentley Systems, Incorporated. The initiative aims to accelerate the creation of digital twins by nurturing new ventures, making minority investments through Bentley iTwin Ventures, and acquiring digital integrators. Bentley iTwin Ventures, a $100 million corporate venture capital fund, co-invests in startups relevant to advancing infrastructure through digital transformation, focusing on early and mid-stage companies in public works, utilities, industrial, and resources infrastructure. The initiative leverages Bentley's iTwin Platform, encouraging innovation and ecosystem development around digital twins. Bentley Systems recently acquired eagle.io, expanding its capabilities. By empowering infrastructure digital twins, the Acceleration Initiatives aim to create a comprehensive ecosystem and drive technological advancements within the industry.

Bentley Systems Acceleration Initiatives's Website
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48) Carbondale Technology Transfer Center

Carbondale Technology Transfer Center - enabling start-ups to fundraise successfully

Established in June 1996 in Carbondale, Pennsylvania, this vital business incubator is dedicated to nurturing new and growing businesses and entrepreneurs. It supports over 50 businesses both on-site and off-site, focusing on enhancing a diverse range of industries including consumer electronics, food and beverage, and general technology. The center provides essential facilities, equipment, and technical support, as well as business assistance, guided financing access, and targeted training. Notably, it features a shared-use, licensed commercial kitchen equipped with state-of-the-art equipment, an adaptable Light Industry Center with overhead and loading bay access, and a shared-use electronic makerspace for Surface Mounted Technology prototyping. Additionally, office assistance is available to entrepreneurs, ensuring they have the necessary support to thrive. Through its comprehensive resources and commitment to fostering entrepreneurship in Northeastern Pennsylvania, the organization plays a crucial role in the region's economic development.

Carbondale Technology Transfer Center's Website
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Top Reasons Start-ups Participate In Accelerators

Learning about market forces

The market seems fair from a distance. But there are certain patterns to how it operates.

Early state financing

Big ideas arise mostly when you don’t have to worry about day to day expenses.

Network expansion

Your net-worth is greatly determined by your network.

Investor connect

Accelerators give an opening to many locked doors.

Why an accelerator might not be right for you

It's usually helpful to consider potential pitfalls. Some common misconceptions

Only you feel the punch

Everybody has a plan till they get punched in the face. Strategy & accelerators can only guide you to a point. No one else will feel the struggle as you would.

Figuring out the failure rates

Everyone can point to a few success stories. Though in general 95% of all start-ups fail. An important question is- what %ge of an accelerator's start-up survive after 3 years.

Are you really important for them?

An accelerator or investor can hedge their bets by investing in multiple start-ups, but as a founder your start-up is your only bet.

FAQs About Start-up Accelerators

Want a curated list of free resources shared at the world’s best accelerators?

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Accelerators and Incubators in pennsylvania

Looking for the best accelerators in Pennsylvania? There are numerous reasons to choose an accelerator to kickstart your startup journey. From access to funding and resources to mentorship and networking opportunities, accelerators provide a supportive ecosystem for early-stage ventures. Pennsylvania boasts a vibrant start-up culture with a thriving entrepreneurial community that fosters innovation and growth. When choosing the right accelerator for your start-up, consider factors such as industry focus, mentorship quality, network strength, and success stories. With a plethora of accelerators to choose from in Pennsylvania, it's essential to align your goals and values with those of the accelerator to maximize your chances of success. Some notable start-ups that have emerged successfully from Pennsylvania include Duolingo, Warby Parker, and Venmo. These success stories demonstrate the potential for growth and innovation within the state's start-up ecosystem, making Pennsylvania a compelling destination for aspiring entrepreneurs.

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